1) Pick up to 15 pairings you like
2) Describe them in up to 15 words
3) Get your friends to guess
Only 12 are in my current "watch list" - all het pairings:
1) She has the job he almost interviewed for but he doesn't know it. (Wendy Watson/Tyler Ford - The Middleman -
2) If it were up to me, they'd be together in any universe. (Clark/Lois - Superman -
3) In order to help her and his dead love, they're on the run. (Julie/Dillon - Terry Moore's Echo - no one)
4) Beauty and the Geek in sitcom form. (Penny/Sheldon, Big Bang Theory -

5) The only thing that stands between sex and this person is clothes - him, too. (Robin/Barney - How I Met Your Mother -
6) Friends in high school, teammates then and now, finally together. (Mark/Eve - Invincible -
7) She knows his secret identity, he's mistaken about hers. (Mayday/JJ - Spider-Girl -
8) Beauty and the Geek in dramedy form. ;) (Chuck/Sarah - Chuck -
9) More TV breakups and makeups than Ross and Rachel, but the kid isn't hers. (JD/Elliot - Scrubs -
10) It's canon! Whoops, not anymore. (Peter/Mary Jane, Spider-Man -
11) Both full of fire and spunk - and they can at least touch. (Olive/Emerson - Pushing Daisies - no one)
12) Reading about this hero's best friends is even more fun. (Brenda/Paco - Blue Beetle -
Hints:
From TV: 6
From comics: 4
From TV/movies/cartoon/comics combos: 2
I will update as people guess correctly!